Interleukin-12 elicits a non-canonical response in B16 melanoma cells to enhance survival
Abstract Background Oncogenesis rewires signaling networks to confer a fitness advantage to malignant cells.For instance, the B16F0 melanoma cell model creates a cytokine sink for Interleukin-12 (IL-12) to deprive neighboring cells of this important anti-tumor immune signal.While a cytokine sink provides an indirect fitness advantage, does IL-12 pr